Protein Details: Transient receptor potential cation channel subfamily M member 2

Protein ID

ICDB_Pro_1360

Protein Name

Transient receptor potential cation channel subfamily M member 2

Gene Name

Trpm2; Ltrpc2; Trpc7

Organism

Mus musculus (Mouse)

Length

1506 amino acids

AlphaFoldDB

AF-Q91YD4-F1-model_v4.pdb

Function

Sequence

MESLDRRRTGSEQEEGFGVQSRRATDLGMVPNLRRSNSSLCKSRRFLCSFSSEKQENLSSWIPENIKKKECVYFVESSKLSDAGKVVCACGYTHEQHLEVAIKPHTFQGKEWDPKKHVQEMPTDAFGDIVFTDLSQKVGKYVRVSQDTPSSVIYQLMTQHWGLDVPNLLISVTGGAKNFNMKLRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSCKEGEVITIGVATWGTIHNREGLIHPMGGFPAEYMLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIYNAINNGTPCVIVEGSGRVADVIAQVATLPVSEITISLIQQKLSIFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTIFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFTDEWQWKPADLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYENLEPSCLFHSKLQKVLAEEQRLAYASATPRLHMHHVAQVLRELLGDSTQLLYPRPRYTDRPRLSMTVPHIKLNVQGVSLRSLYKRSTGHVTFTIDPVRDLLIWAVIQNHRELAGIIWAQSQDCTAAALACSKILKELSKEEEDTDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLCVDNGLWRIILCMLAFPLLFTGFISFREKRLQALCRPARVRAFFNAPVVIFHMNILSYFAFLCLFAYVLMVDFQPSPSWCEYLIYLWLFSLVCEETRQLFYDPDGCGLMKMASLYFSDFWNKLDVGAILLFIVGLTCRLIPATLYPGRIILSLDFIMFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNESRVDWIFRGVVYHSYLTIFGQIPTYIDGVNFSMDQCSPNGTDPYKPKCPESDWTGQAPAFPEWLTVTLLCLYLLFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQRHDLIEEYHGRPPAPPPLILLSHLQLLIKRIVLKIPAKRHKQLKNKLEKNEETALLSWELYLKENYLQNQQYQQKQRPEQKIQDISEKVDTMVDLLDMDQVKRSGSTEQRLASLEEQVTQVTRALHWIVTTLKDSGFGSGAGALTLAPQRAFDEPDAELSIRRKVEEPGDGYHVSARHLLYPNARIMRFPVPNEKVPWAAEFLIYDPPFYTAEKDVALTDPVGDTAEPLSKISYNVVDGPTDRRSFHGVYVVEYGFPLNPMGRTGLRGRGSLSWFGPNHTLQPVVTRWKRNQGGAICRKSVRKMLEVLVMKLPRSEHWALPGGSREPGEMLPRKLKRVLRQEFWVAFETLLMQGTEVYKGYVDDPRNTDNAWIETVAVSIHFQDQNDMELKRLEENLHTHDPKELTRDLKLSTEWQVVDRRIPLYANHKTILQKVASLFGAHF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

840;843;866;1070

Disease

Location

Detected in the preoptic area of the hypothalamus; a brain area involved in body temperature control. Detected in beta-cells in pancreas islets (at protein level). Detected in brain cortex; striatum; hippocampus CA1; CA2 and CA3 layers; and in the Purkinje cell layer in cerebellum. Detected in brain cortex; striatum; hippocampus CA1; CA2 and CA3 layers; and in the Purkinje cell layer in cerebellum. Detected in brain cortex; striatum; hippocampus CA1; CA2 and CA3 layers; and in the Purkinje cell layer in cerebellum. Widely expressed; with highest levels in lung; spleen; eye and brain. Detected in dendritic cells and in polymorphonuclear neutrophils. .

DOI ID

10.1016/j.bbrc.2005.01.086; 10.1016/j.neuropharm.2005.08.021; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/s1097-2765(01)00438-5; 10.1038/sj.emboj.7601083; 10.1126/scisignal.2000278; 10.2337/db10-0276; 10.1096/fj.10-178483; 10.1073/pnas.1010678108; 10.1073/pnas.1114193109; 10.1042/bj20140747; 10.1074/jbc.m115.649913; 10.1038/nature19074; 10.1126/science.aaf7537

RefSeq

NP_612174.2;